ACE-Gene Polymorphism and Endothelial Dysfunction in Normal Humans
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چکیده
منابع مشابه
ACE-gene polymorphism and endothelial dysfunction in normal humans.
ACE-Gene Polymorphism and Endothelial Dysfunction in Normal Humans To the Editor: Recently, Butler et al1 have reported that the DD angiotensinconverting enzyme (ACE) genotype in a young normal population is associated with a blunted vasodilator response both to acetylcholine (ACh) and sodium nitroprusside. These data disagree with findings previously reported by ourselves.2 In fact, in our art...
متن کاملDD angiotensin-converting enzyme gene polymorphism is associated with endothelial dysfunction in normal humans.
A polymorphism within the angiotensin-converting enzyme (ACE) gene may increase the risk of myocardial infarction in individuals previously thought to be at low cardiovascular risk. The mechanism through which it exerts this effect is unknown but may be due to increased angiotensin II-induced nitric oxide (NO) breakdown and/or reduced bradykinin-mediated NO release. We investigated whether endo...
متن کاملInsertion-deletion polymorphism of the ACE gene modulates reversibility of endothelial dysfunction with ACE inhibition.
BACKGROUND The aim of this study was to examine whether angiotensin-converting enzyme (ACE) inhibition improves coronary endothelial dysfunction in patients with atherosclerosis and its risk factors and whether this was related to the ACE insertion-deletion (I/D) polymorphism. METHODS AND RESULTS In 56 patients with atherosclerosis or its risk factors, we studied endothelium-dependent respons...
متن کاملDD ACE gene polymorphism is associated with increased coronary artery endothelial dysfunction: the PREFACE trial.
Endothelial dysfunction is an early event in atherogenesis and is associated with the propensity to cause future cardiovascular events. The amelioration of endothelial dysfunction has been a research target for some years now, and success has been reported with, for example, the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Research has also identified the homozygous del...
متن کاملExclusion of the ACE D/I gene polymorphism as a determinant of endothelial dysfunction.
A deletion/insertion (D/I) polymorphism within the ACE gene may increase the risk of cardiovascular events through still unknown mechanisms. The latter may involve increased angiotensin II-induced NO breakdown and/or reduced agonist-mediated NO release. We therefore investigated whether the D allele of the ACE gene affects endothelium-dependent vasodilatation in mild-to-moderate primary hyperte...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1999
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.34.6.e20